GEN Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family| whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered C-terminal domains. The protein encoded by this gene is involved in resolution of Holliday junctions| which are intermediate four-way structures that covalently link DNA during homologous recombination and double-strand break repair. The protein resolves Holliday junctions by creating dual incisions across the junction to produce nicked duplex products that can be ligated. In addition| this protein has been found to localize to centrosomes where it has been implicated in regulation of centrosome integrity. Alternative splicing results in multiple transcript variants.

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human GEN

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

99880

synonyms

GEN