GDF5 Antibody

Size

100ul

Clone Number

Aliases

BMP14 antibody; Cartilage derived morphogenetic protein 1 antibody; Cartilage-derived morphogenetic protein 1 antibody; CDMP-1 antibody; CDMP1 antibody; GDF-5 antibody; Gdf5 antibody; GDF5_HUMAN antibody; Growth differentiation factor 5 antibody; Growth/differentiation factor 5 antibody; LAP4 antibody; OS5 antibody; Radotermin antibody; SYNS2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P43026

Immunogen

Recombinant Human Growth/differentiation factor 5 protein (202-501AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:20-1:200

Background

Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GDF5

Research Areas

Cardiovascular; Signal transduction; Stem cells