GDF-5 Polyclonal Antibody

Ab type

Primary antibody

Background

GDF5 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Growth/differentiation factor 5 regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis.

Reactivity

Human;Mouse;Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human GDF5. AA range:361-410

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

55411

synonyms

GDF5; CDMP1; Growth/differentiation factor 5; GDF-5; Cartilage-derived morphogenetic protein 1; CDMP-1; Radotermin