GCK Antibody

Size

100ul

Clone Number

Aliases

ATP:D-hexose 6-phosphotransferase antibody; FGQTL3 antibody; GCK antibody; GK antibody; GLK antibody; Glucokinase antibody; Hexokinase D pancreatic isozyme antibody; Hexokinase type IV antibody; Hexokinase-4 antibody; Hexokinase-D antibody; HHF3 antibody; HK IV antibody; HK4 antibody; HKIV antibody; HXK4_HUMAN antibody; HXKP antibody; LGLK antibody; MODY2 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P35557

Immunogen

Recombinant Human Glucokinase protein (1-300AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:200-1:1000, IHC:1:20-1:200

Background

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GCK

Research Areas

Cancer; Metabolism; Signal transduction