GABBR2 Antibody

Size

100ul

Clone Number

Aliases

BcDNA:GH07312 antibody; CG6706 antibody; CT20836 antibody; D Gaba2 antibody; FLJ36928 antibody; G protein coupled receptor 51 antibody; G-protein coupled receptor 51 antibody; GAB B R2 antibody; GABA B R2 antibody; GABA B receptor 2 antibody; GABA-B receptor 2 antibody; GABA-B-R2 antibody; GABA-BR2 antibody; GABAB R2 antibody; GABABR 2 antibody; GABABR2 antibody; GABB R2 antibody; GABBR 2 antibody; Gabbr2 antibody; GABR2_HUMAN antibody; Gamma aminobutyric acid B receptor 2 antibody; Gamma aminobutyric acid GABA B receptor 2 antibody; Gamma aminobutyric acid type B receptor subunit 2 antibody; Gamma-aminobutyric acid type B receptor subunit 2 antibody; Gb 2 antibody; Gb2 antibody; GH07312 antibody; GPR 51 antibody; GPR51 antibody; GPRC 3B antibody; GPRC3B antibody; HG 20 antibody; HG20 antibody; HRIHFB2099 antibody; Metabotropic GABA B receptor subtype 2 antibody; OTTHUMP00000021776 antibody; OTTHUMP00000063797 antibody; R2 SUBUNIT antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O75899

Immunogen

Recombinant Human Gamma-aminobutyric acid type B receptor subunit 2 protein (60-310AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

GABBR2

Research Areas

Neuroscience