FZD9 Antibody

Size

100ug

Clone Number

Aliases

CD 349 antibody; CD 349 antigen antibody; CD349 antibody; Frizzled Drosophila homolog of 3 antibody; Frizzled homolog 9 (Drosophila) antibody; Frizzled homolog 9 antibody; Frizzled-9 antibody; Fz 9 antibody; Fz-9 antibody; FZD 3 antibody; Fzd 9 antibody; FZD3 antibody; FZD3-PEN antibody; FZD9 antibody; FZD9_HUMAN antibody; FzE6 antibody; hFz9 antibody; mfz9 antibody; Xfz9 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O00144

Immunogen

Recombinant Human Frizzled-9 protein (23-229AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000

Background

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FZD9

Research Areas

Neuroscience; Stem cells