FZD8 Antibody

Size

100ug

Clone Number

Aliases

Frizzled 8 seven transmembrane spanning receptor antibody; frizzled 8, seven transmembrane spanning receptor antibody; Frizzled family receptor 8 antibody; frizzled homolog 8 (Drosophila) antibody; Frizzled homolog 8 antibody; Frizzled-8 antibody; FZ 8 antibody; Fz-8 antibody; FZ8 antibody; FZD 8 antibody; FZD8 antibody; FZD8_HUMAN antibody; hFZ 8 antibody; hFz8 antibody; HGNC4046 antibody; Homolog of Drosophila Frizzled 8 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9H461

Immunogen

Recombinant Human Frizzled-8 protein (55-233AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Background

Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FZD8

Research Areas

Others