PDGFRα Mouse Monoclonal Antibody(7A3)

Condition: 1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.
Store at: Store at -20°C. Stable for one year from the date of shipment.
Recommended dilutions: IHC 1:100-200
Specificity: Antibody can detect endogenous PDGFRα proteins.
Alternative Names: nan
Background: Platelet derived growth factor (PDGF) family proteins exist as several disulphide-bonded,dimeric isoforms (PDGF AA,PDGF AB,PDGF BB,PDGF CC,and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases,PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). PDGFRα and PDGFRβ can each form heterodimers with EGFR,which is also activated by PDGF. Various cells differ in the total number of receptors present and in the receptor subunit composition,which may account for responsive differences among cell types to PDGF binding. Ligand binding induces receptor dimerization and autophosphorylation,followed by binding and activation of cytoplasmic SH2 domain-containing signal transduction molecules,such as GRB2,Src,GAP,PI3 kinase,PLCγ,and NCK. A number of different signaling pathways are initiated by activated PDGF receptors and lead to control of cell growth,actin reorganization,migration,and differentiation.
Applications: IHC
Species Cross-Reactivity: H,M,R
Molecular Weight: 180KD
Isotype: IgG1
Protein MW （KDa）: 180KD
SWISS: P16234
Source: Mouse
Antigen: Synthetic Peptide
Category: Monoclonal
Catalog Number: FY-IG0237
Title: PDGFRα Mouse Monoclonal Antibody(7A3)
Size List: ['50', '100']