FRS2(Phospho Tyr436) Polyclonal Antibody

Ab type

Primary antibody

Background

Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence Translated as stop.,Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.,

Reactivity

Human, Mouse, Monkey

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human FRS2 around the phosphorylation site of Tyr436. AA range:402-451

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

57528

synonyms

Fibroblast growth factor receptor substrate 2; FRS2; Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1