Frizzled-7 Polyclonal Antibody

Ab type

Primary antibody

Background

Members of the frizzled gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Frizzled-7 contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

Reactivity

Human;Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human FZD7. AA range:45-94

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

63620

synonyms

FZD7; Frizzled-7; Fz-7; hFz7; FzE3