FOXP3 Monoclonal Antibody

Size

Clone Number

Aliases

JM2; AIID; IPEX; PIDX; XPID; DIETER; MGC141961; MGC141963; FOXP3

Immunogen Species

Human

UniProt ID

Q9BZS1

Immunogen

Synthetic peptide conjugated to KLH derived from Human Heme Oxygenase 1.

Raised in

Mouse

Species Reactivity

Human

Tested Applications

ELISA,WB;Recommended dilution:WB:1:500-1:5000

Background

FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.

Clonality

Monoclonal

Isotype

IgG1

Purification Method

Affinity-chromatography

Conjugate

Non-conjugated

Buffer

Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20?C. Stable for 12 months from date of receipt.

Form

liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FOXP3

Research Areas

Epigenetics and Nuclear Signaling;Cell biology;Immunology