FOXA3 Antibody

Size

100ug

Clone Number

Aliases

FKHH3 antibody; Fork head-related protein FKH H3 antibody; forkhead box A3 antibody; Forkhead box protein A3 antibody; Foxa3 antibody; FOXA3_HUMAN antibody; hepatic nuclear factor-3-beta antibody; hepatocyte nuclear factor 3 antibody; hepatocyte nuclear factor 3 gamma antibody; Hepatocyte nuclear factor 3-gamma antibody; HNF-3-gamma antibody; HNF-3G antibody; HNF3B antibody; HNF3G antibody; TCF-3G antibody; TCF3G antibody; Transcription factor 3G antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P55318

Immunogen

Recombinant Human Hepatocyte nuclear factor 3-gamma protein (220-336AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:500-1:1000

Background

Transcription factor that is thought to act as a \\\'pioneer\\\' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FOXA3

Research Areas

Epigenetics and Nuclear Signaling