Flt-1(Phospho Tyr1048) Polyclonal Antibody

Ab type

Primary antibody

Background

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains| a transmembrane segment| and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A| VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells| placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened| soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human VEGFR1 around the phosphorylation site of Tyr1048. AA range:1016-1065

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

150769

synonyms

Vascular endothelial growth factor receptor 1; FLT1; FLT; FRT; VEGFR1; Vascular endothelial growth factor receptor 1; VEGFR-1; Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; FLT; Vascular permeability factor receptor