FKBP8 Antibody

Size

100ug

Clone Number

Aliases

38 kDa FK506-binding protein antibody; 38 kDa FKBP antibody; 38kDa antibody; FK506 binding protein 8 antibody; FK506 binding protein 8, 38kDa antibody; FK506 binding protein, 38kDa antibody; FK506-binding protein 8 antibody; FKBP 38 antibody; FKBP-38 antibody; FKBP-8 antibody; Fkbp8 antibody; FKBP8_HUMAN antibody; FKBPR38 antibody; hFKBP38 antibody; Peptidyl-prolyl cis-trans isomerase FKBP8 antibody; PPIase FKBP8 antibody; Rotamase antibody; Sam11 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q14318

Immunogen

Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP8 protein (58-190AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Background

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FKBP8

Research Areas

Cell biology; Signal transduction