FILA2 Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The filaggrin-like protein encoded by this gene is upregulated by calcium| proteolyzed by calpain 1| and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin| with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact| in addition to providing a physical barrier| C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa.

Reactivity

Human, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human FILA2

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

263010

synonyms

FILA2