FHR5 Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties| a region within repeats 5-7 having heparin binding and C reactive protein binding properties| and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3| binds C3b in a dose-dependent manner| and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated| but not causally linked| with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).

Reactivity

Human, Rat, Mouse

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human FHR5

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

synonyms

FHR5; Complement factor H-related protein 5; FHR-5