FGFR4 Antibody

Size

100ug

Clone Number

Aliases

CD 334 antibody; CD334 antibody; CD334 antigen antibody; fc13h 10 antibody; fc13h10 antibody; Fgfr 4 antibody; FGFR-4 antibody; Fgfr4 antibody; FGFR4_HUMAN antibody; Fibroblast growth factor receptor 4 antibody; Hydroxyaryl protein kinase antibody; JTK 2 antibody; JTK2 antibody; MGC20292 antibody; Protein tyrosine kinase antibody; TKF antibody; Tyrosine kinase related to fibroblast growth factor receptor antibody; Tyrosylprotein kinase antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

P22455

Immunogen

Recombinant Human Fibroblast growth factor receptor 4 protein (25-182AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FGFR4

Research Areas

Neuroscience; Cancer; Cardiovascular; Cell biology; Tags & Cell Markers; Signal transduction; Stem cells