FGFR-4(Phospho Tyr642) Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene is a member of the fibroblast growth factor receptor family| where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region| composed of three immunoglobulin-like domains| a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors| setting in motion a cascade of downstream signals| ultimately influencing mitogenesis and differentiation. The genomic organization of this gene| compared to members 1-3| encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed| there is no evidence that the C-terminal half of the IgII

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human FGFR-4 (phospho Tyr642)

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

87954

synonyms

Fibroblast growth factor receptor 4; FGFR4; JTK2; TKF; Fibroblast growth factor receptor 4; FGFR-4; CD antigen CD334