FERMT2 Antibody

Size

100ug

Clone Number

Aliases

FLJ34213 antibody; FLJ44462 antibody; UNC112 antibody; FERM2_HUMAN antibody; Fermitin family homolog 2 antibody; Fermt2 antibody; KIND2 antibody; Kindlin-2 antibody; MIG-2 antibody; MIG2 antibody; Mitogen-inducible gene 2 protein antibody; PH domain-containing family C member 1 antibody; Pleckstrin homology domain containing family C (with FERM domain) member 1 antibody; Pleckstrin homology domain-containing family C member 1 antibody; PLEKHC1 antibody; UNC112B antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q96AC1

Immunogen

Recombinant Human Fermitin family homolog 2 protein (155-232AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC, IF; Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200

Background

Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FERMT2

Research Areas

Signal transduction; Stem cells