FCN1 Antibody

Size

100ul

Clone Number

Aliases

Collagen/fibrinogen domain containing protein 1 antibody; Collagen/fibrinogen domain-containing protein 1 antibody; Fcn1 antibody; FCN1_HUMAN antibody; FCNM antibody; ficolin (collagen/fibrinogen domain containing) 1 antibody; Ficolin 1 antibody; Ficolin A antibody; Ficolin alpha antibody; Ficolin-1 antibody; Ficolin-A antibody; Ficolin-alpha antibody; M ficolin antibody; M-ficolin antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O00602

Immunogen

Recombinant Human Ficolin-1 protein (30-326AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FCN1

Research Areas

Immunology