FCMR Antibody

Size

100ul

Clone Number

Aliases

Faim3 antibody; FAIM3_HUMAN antibody; Fas apoptotic inhibitory molecule 3 antibody; Fc fragment of IgM receptor antibody; Fc mu receptor antibody; FCMR antibody; IgM Fc receptor antibody; Immunoglobulin mu Fc receptor antibody; Regulator of Fas induced apoptosis antibody; Regulator of Fas-induced apoptosis Toso antibody; TOSO antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

O60667

Immunogen

Recombinant Human Fas apoptotic inhibitory molecule 3 protein (18-251AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FCMR

Research Areas

Cell biology