FBXO7 Antibody

Size

100ul

Clone Number

Aliases

F box only protein 7 antibody; F box protein 7 antibody; F-box only protein 7 antibody; FBX antibody; FBX07 antibody; FBX7 antibody; FBX7_HUMAN antibody; Fbxo7 antibody; PARK15 antibody; PKPS antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9Y3I1

Immunogen

Recombinant Human F-box only protein 7 protein (353-522AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PARK2 to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FBXO7

Research Areas

Epigenetics and Nuclear Signaling; Cell biology