FBXO2 Antibody

Size

100ul

Clone Number

Aliases

F box gene 1 antibody; F box only protein 2 antibody; F box protein 2 antibody; F box protein only 2 antibody; F-box only protein 2 antibody; FBG 1 antibody; FBG1 antibody; Fbs 1 antibody; Fbs1 antibody; Fbs2 antibody; FBX 2 antibody; FBX2 antibody; FBX2_HUMAN antibody; FBXO 2 antibody; FBXO2 antibody; Neural F box protein NFB42 antibody; Neural F-box protein; 42-KD; rat; homolog of antibody; NFB 42 antibody; NFB42 antibody; OCP1 antibody; organ of Corti protein 1 antibody; Prpl4 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UK22

Immunogen

Recombinant Human F-box only protein 2 protein (1-296AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FBXO2

Research Areas

Cell biology