FBXL5 Antibody

Size

100ul

Clone Number

Aliases

F box and leucine rich repeat protein 5 antibody; F box protein FBL5 antibody; F box/LRR repeat protein 5 antibody; F-box and leucine-rich repeat protein 5 antibody; F-box protein FBL4/FBL5 antibody; F-box/LRR-repeat protein 5 antibody; FBL4 antibody; FBL5 antibody; FBXL5 antibody; FBXL5_HUMAN antibody; FLR1 antibody; p45SKP2 like protein antibody; p45SKP2-like protein antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UKA1

Immunogen

Recombinant Human F-box/LRR-repeat protein 5 protein (1-310AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

Background

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Conjugate

Non-conjugated

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FBXL5

Research Areas

Cell biology