FBXL21 Antibody

Size

100ug

Clone Number

Aliases

F box and leucine rich repeat protein 21 antibody; F box and leucine rich repeat protein 3 pseudogene antibody; F box and leucine rich repeat protein 3B antibody; F box protein Fbl3b antibody; F box/LRR repeat protein 21 antibody; F box/LRR repeat protein 3B antibody; F-box and leucine-rich repeat protein 21 antibody; F-box and leucine-rich repeat protein 3B antibody; F-box/LRR-repeat protein 21 antibody; F-box/LRR-repeat protein 3B antibody; Fbl 21 antibody; FBL 3 antibody; FBL 3B antibody; Fbl21 antibody; FBL3 antibody; FBL3B antibody; FBXL 21 antibody; FBXL 3B antibody; FBXL 3P antibody; Fbxl21 antibody; FBXL3B antibody; FBXL3P antibody; FXL21_HUMAN antibody; MGC120237 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UKT6

Immunogen

Recombinant Human F-box/LRR-repeat protein 21 protein (78-137AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC, IF; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Background

Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FBXL21

Research Areas

Others