FBXL2 Antibody, HRP conjugated

Size

100ug

Clone Number

Aliases

DKFZP564P0622 antibody; F box and leucine rich repeat protein 2 antibody; F box protein containing leucine rich repeats antibody; F box protein FBL2/FBL3 antibody; F box/LRR repeat protein 2 antibody; F-box and leucine-rich repeat protein 2 antibody; F-box protein FBL2/FBL3 antibody; F-box/LRR-repeat protein 2 antibody; FBL 2 antibody; FBL 3 antibody; FBL2 antibody; FBL3 antibody; FBXL 2 antibody; FBXL2 antibody; FBXL2_HUMAN antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9UKC9

Immunogen

Recombinant Human F-box/LRR-repeat protein 2 protein (1-423AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA

Background

Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity).

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

HRP

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FBXL2

Research Areas

Epigenetics and Nuclear Signaling