FANCI Antibody

Size

100ug

Clone Number

Aliases

FANCI antibody; FANCI gene antibody; FANCI_HUMAN antibody; Fanconi anemia group I protein antibody; Fanconi anemia; complementation group I antibody; FLJ10719 antibody; FLJ14658 antibody; KIAA1794 antibody; Protein FACI antibody; Protein FANCI antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NVI1

Immunogen

Recombinant Human Fanconi anemia group I protein (180-252AA)

Raised in

Rabbit

Species Reactivity

Human

Tested Applications

ELISA, IF; Recommended dilution: IF:1:50-1:200

Background

Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

FANCI

Research Areas

Epigenetics and Nuclear Signaling