FAM111B Polyclonal Antibody

Ab type

Primary antibody

Background

FAM111B encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin-like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.

Reactivity

Human

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

The antiserum was produced against synthesized peptide derived from human F111B. AA range:281-330

Storage Stability

-20°C for one year

Concentration

1 mg/ml

MolecularWeight_Da

84674

synonyms

FAM111B; CANP; Protein FAM111B; Cancer-associated nucleoprotein