FACR1 Rabbit Polyclonal Antibody

Ab type

Primary antibody

Background

The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols| a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction| and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein| and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome| while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability| early-onset epilepsy| microcephaly| congenital cataracts| growth retardation| and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13.

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Immunogen

Synthesized peptide derived from human FACR1

Storage Stability

-20°C for 1 year

Concentration

1 mg/ml

MolecularWeight_Da

56650

synonyms

FACR1