EXD2 Antibody

Size

100ug

Clone Number

Aliases

4930539P14Rik antibody; C14orf114 antibody; C85658 antibody; DKFZp781A0133 antibody; DKFZp781L15100 antibody; Exd2 antibody; EXD2_HUMAN antibody; EXDL2 antibody; Exonuclease 3''-5'' domain-containing protein 2 antibody; Exonuclease 3''-5'' domain-like-containing protein 2 antibody; exonuclease 3'-5' domain-like 2 antibody; FLJ10738 antibody; RGD1311087 antibody

Immunogen Species

Homo sapiens (Human)

UniProt ID

Q9NVH0

Immunogen

Recombinant Human Exonuclease 3\\\'-5\\\' domain-containing protein 2 protein (137-245AA)

Raised in

Rabbit

Species Reactivity

Human, Mouse

Tested Applications

ELISA, WB, IHC; Recommended dilution: WB:1:2000-1:10000, IHC:1:20-1:200

Background

Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3\\\'-5\\\' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Conjugate

Non-conjugated

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Stroage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names

EXD2

Research Areas

Epigenetics and Nuclear Signaling