MUC4 rabbit pAb

Applications: WB;ELISA
Reactivity: Human;Rat;Mouse;
Source: Rabbit
Dilution: WB 1:500-2000 ELISA 1:5000-20000
Immunogen: Synthesized peptide derived from human protein . at AA range: 1970-2050
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 238kD
Human_gene_id: 4585
Human_swiss_prot_no: Q99102
Subcellular_location: [Mucin-4 beta chain]: Cell membrane ; Single-pass membrane protein . Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing. .; [Mucin-4 alpha chain]: Cell membrane . Secreted . Forms a complex with Mucin-4 beta chain at the cell membrane. .; [Isoform 3]: Cell membrane ; Single-pass membrane protein .; [Isoform 11]: Secreted .; [Isoform 15]: Secreted .; [Isoform 17]: Cell membrane ; Single-pass membrane protein .
Background: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008],