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ELK Biotechnology

SKU:ES8931

MYBPC3 rabbit pAb

MYBPC3 rabbit pAb

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Size
Applications: WB;IHC
Reactivity: Human;Mouse;Rat
Source: Rabbit
Dilution: WB 1:500-2000;IHC-p 1:50-300
Immunogen: Synthesized peptide derived from human MYBPC3 Polyclonal
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 140kD
Human_gene_id: 4607
Human_swiss_prot_no: Q14896
Subcellular_location: cytosol,striated muscle myosin thick filament,C zone,sarcomere,A band,
Other_name: Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)
Background: MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008],
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