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ELK Biotechnology
SKU:ES8652
RANK rabbit pAb
RANK rabbit pAb
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$250.00 USD
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Applications: WB;IHC;IF;ELISA
Reactivity: Human;Mouse;Rat
Source: Rabbit
Dilution: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000
Immunogen: Synthetic peptide from human protein at AA range: 60-120
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 66kD
Human_gene_id: 8792
Human_swiss_prot_no: Q9Y6Q6
Subcellular_location: [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform RANK-e5a]: Cell membrane ; Single-pass type I membrane protein .
Other_name: Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor;ODFR;Receptor activator of NF-KB;CD antigen CD265)
Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012],
Reactivity: Human;Mouse;Rat
Source: Rabbit
Dilution: WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000
Immunogen: Synthetic peptide from human protein at AA range: 60-120
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 66kD
Human_gene_id: 8792
Human_swiss_prot_no: Q9Y6Q6
Subcellular_location: [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform RANK-e5a]: Cell membrane ; Single-pass type I membrane protein .
Other_name: Tumor necrosis factor receptor superfamily member 11A (Osteoclast differentiation factor receptor;ODFR;Receptor activator of NF-KB;CD antigen CD265)
Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012],
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