ETBR rabbit pAb

Applications: WB;IHC;IF;ELISA
Reactivity: Human;Rat;Mouse;
Source: Rabbit
Dilution: IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000
Immunogen: Synthesized peptide derived from ETBR at AA range: 31-80
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 50kD
Human_gene_id: 1910
Human_swiss_prot_no: P24530
Subcellular_location: Cell membrane ; Multi-pass membrane protein. internalized after activation by endothelins. .
Other_name: Endothelin B receptor (ET-B;ET-BR;Endothelin receptor non-selective type)
Background: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016],