RO60 rabbit pAb

Applications: WB;IHC
Reactivity: Human;Rat;Mouse;
Source: Rabbit
Dilution: WB 1:500-2000;IHC-p 1:50-300
Immunogen: The antiserum was produced against synthesized peptide derived from human TROVE2. AA range:311-360
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 70kD
Human_gene_id: 6738
Human_swiss_prot_no: P10155
Subcellular_location: Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .
Other_name: TROVE2; RO60; SSA2; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa Ro protein; 60 kDa ribonucleoprotein Ro; RoRNP; Ro 60 kDa autoantigen; Sjoegren syndrome antigen A2; Sjoegren syndrome type A antigen; SS-A; TROVE domain family member 2
Background: disease:Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular SSA2 protein as if this antigen was foreign.,function:RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the Ro 60 kDa family.,similarity:Contains 1 TROVE domain.,subunit:Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.,