LARG rabbit pAb

Applications: WB;IHC
Reactivity: Human;Mouse;Rat
Source: Rabbit
Dilution: WB 1:500-2000;IHC-p 1:50-300
Immunogen: The antiserum was produced against synthesized peptide derived from human ARHGEF12. AA range:449-498
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 173kD
Human_gene_id: 23365
Human_swiss_prot_no: Q9NZN5
Subcellular_location: Cytoplasm . Membrane . Translocated to the membrane upon stimulation. .
Other_name: ARHGEF12; KIAA0382; LARG; Rho guanine nucleotide exchange factor 12; Leukemia-associated RhoGEF
Background: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],