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ELK Biotechnology
SKU:ES5237
ZNRF2 rabbit pAb
ZNRF2 rabbit pAb
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$250.00 USD
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Applications: IHC;IF;ELISA
Reactivity: Human;Mouse
Source: Rabbit
Dilution: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human ZNRF2. AA range:161-210
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Human_gene_id: 223082
Human_swiss_prot_no: Q8NHG8
Subcellular_location: Endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Cell junction, synapse, presynaptic cell membrane ; Peripheral membrane protein .
Other_name: ZNRF2; RNF202; E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; Zinc/RING finger protein 2
Background: domain:The RING-type zinc finger domain is required for E3 ligase activity.,function:May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Present in presynaptic plasma membranes in neurons.,subunit:Interacts with UBE2N.,tissue specificity:Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.,
Reactivity: Human;Mouse
Source: Rabbit
Dilution: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human ZNRF2. AA range:161-210
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Human_gene_id: 223082
Human_swiss_prot_no: Q8NHG8
Subcellular_location: Endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Cell junction, synapse, presynaptic cell membrane ; Peripheral membrane protein .
Other_name: ZNRF2; RNF202; E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; Zinc/RING finger protein 2
Background: domain:The RING-type zinc finger domain is required for E3 ligase activity.,function:May play a role in the establisment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Present in presynaptic plasma membranes in neurons.,subunit:Interacts with UBE2N.,tissue specificity:Highly expressed in the brain, with higher expression during development than in adult. Expressed also in mammary glands, testis, colon and kidney.,
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