Nesprin-3 rabbit pAb

Applications: WB;IF;ELISA
Reactivity: Human;Mouse
Source: Rabbit
Dilution: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human C14orf49. AA range:169-218
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 115kD
Human_gene_id: 161176
Human_swiss_prot_no: Q6ZMZ3
Subcellular_location: Nucleus outer membrane ; Single-pass type IV membrane protein . Nucleus envelope . Rough endoplasmic reticulum .
Other_name: SYNE3; C14orf49; Nesprin-3; Nuclear envelope spectrin repeat protein 3
Background: function:Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which theters the nucleus to the cytoskeleton by binding PLEC1/Plectin which can associate with the intermediate filament system.,similarity:Belongs to the nesprin family.,similarity:Contains 1 KASH domain.,similarity:Contains 2 spectrin repeats.,subcellular location:Located at the rough reticulum endoplasmic (RER) in some cells.,subunit:Interacts with actin-binding domain of PLEC1/plectin.,