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ELK Biotechnology

SKU:ES2930

Neurofibromin rabbit pAb

Neurofibromin rabbit pAb

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Size
Applications: WB;IHC
Reactivity: Human;Mouse;Rat
Source: Rabbit
Dilution: WB 1:500-2000;IHC-p 1:50-300
Immunogen: The antiserum was produced against synthesized peptide derived from human NF1. AA range:1551-1600
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 319kD
Human_gene_id: 4763
Human_swiss_prot_no: P21359
Subcellular_location: Nucleus . Nucleus, nucleolus .
Other_name: NF1; Neurofibromin; Neurofibromatosis-related protein NF-1
Background: This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008],
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