LRRC41 rabbit pAb

Applications: WB;IHC;IF;ELISA
Reactivity: Human;Mouse;Rat
Source: Rabbit
Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human LRRC41. AA range:391-440
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 80kD
Human_gene_id: 10489
Human_swiss_prot_no: Q15345
Subcellular_location: nucleus,cytoplasm,membrane,
Other_name: LRRC41; MUF1; PP7759; Leucine-rich repeat-containing protein 41; Protein Muf1
Background: caution:It is uncertain whether Met-1 or Met-23 is the initiator.,domain:The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].,function:Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translation N-terminally extended.,similarity:Contains 7 LRR (leucine-rich) repeats.,subunit:Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2.,