Bmi-1 Rabbit pAb(F270)

Applications: WB
Reactivity: Human
Source: Rabbit
Dilution: WB 1:500-2000
Immunogen: Recombinant Protein derived from human Bmi-1
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 37-43kD
Human_gene_id: 100532731
Human_swiss_prot_no: P35226
Subcellular_location: Nucleus . Cytoplasm .
Other_name: Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Background: BMI1 proto-oncogene, polycomb ring finger(BMI1) Homo sapiens This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015],