Cav1.3 rabbit pAb

Applications: IHC;IF
Reactivity: Human;Rat;Mouse
Source: Rabbit
Dilution: IHC 1:100-200
Immunogen: Synthetic Peptide of Cav1.3 AA range: 1060-1140
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 245kD
Human_gene_id: 776
Human_swiss_prot_no: Q01668
Subcellular_location: Membrane ; Multi-pass membrane protein .
Other_name: Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2;Voltage-gated calcium channel subunit alpha Cav1.3)
Background: calcium voltage-gated channel subunit alpha1 D(CACNA1D) Homo sapiens Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],