Cav3.2 rabbit pAb

Applications: IHC;IF
Reactivity: Human;Rat;Mouse
Source: Rabbit
Dilution: IHC 1:50-100
Immunogen: Synthetic Peptide of Cav3.2 AA range: 1718-1768
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 260kD
Human_gene_id: 8912
Human_swiss_prot_no: O95180
Subcellular_location: Cell membrane ; Multi-pass membrane protein . Interaction with STAC increases expression at the cell membrane. .
Other_name: CACNA1H; Voltage-dependent T-type calcium channel subunit alpha-1H; Low-voltage-activated calcium channel alpha1 3.2 subunit; Voltage-gated calcium channel subunit alpha Cav3.2
Background: calcium voltage-gated channel subunit alpha1 H(CACNA1H) Homo sapiens This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq, Jul 2008],