CNTF rabbit pAb

Applications: WB
Reactivity: Human;Rat;Mouse
Source: Rabbit
Dilution: WB 1:500-1000
Immunogen: Synthetic Peptide of CNTF
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 30kD
Human_gene_id: 1270
Human_swiss_prot_no: P26441
Subcellular_location: Cytoplasm.
Other_name: CNTF; Ciliary neurotrophic factor; CNTF
Background: The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010],