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ELK Biotechnology
SKU:ES20771
EAAT2 rabbit pAb
EAAT2 rabbit pAb
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Applications: WB
Reactivity: Human;Rat;Mouse
Source: Rabbit
Dilution: WB 1:1000-2000
Immunogen: Synthetic Peptide of EAAT2 AA range: 370-420
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 62kD
Human_gene_id: 6506
Human_swiss_prot_no: P43004
Subcellular_location: Cell membrane ; Multi-pass membrane protein .
Other_name: Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
Background: This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],
Reactivity: Human;Rat;Mouse
Source: Rabbit
Dilution: WB 1:1000-2000
Immunogen: Synthetic Peptide of EAAT2 AA range: 370-420
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 62kD
Human_gene_id: 6506
Human_swiss_prot_no: P43004
Subcellular_location: Cell membrane ; Multi-pass membrane protein .
Other_name: Excitatory amino acid transporter 2 (Glutamate/aspartate transporter II) (Sodium-dependent glutamate/aspartate transporter 2) (Solute carrier family 1 member 2)
Background: This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],
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