Ghrelin Receptor rabbit pAb

Applications: WB;IHC;IF
Reactivity: Human;Rat;Mouse
Source: Rabbit
Dilution: WB 1:1000-2000, IHC 1:100-200
Immunogen: Synthetic Peptide of Ghrelin Receptor AA range: 290-370
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 41kD
Human_gene_id: 2693
Human_swiss_prot_no: Q92847
Subcellular_location: Cell membrane; Multi-pass membrane protein.
Other_name: Growth hormone secretagogue receptor type 1 (GHS-R;GH-releasing peptide receptor;GHRP;Ghrelin receptor)
Background: This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010],