KCNN3 (SK3) rabbit pAb

Applications: IHC;IF
Reactivity: Human;Rat
Source: Rabbit
Dilution: IHC 1:100-200
Immunogen: Synthetic Peptide of KCNN3 (SK3) AA range: 161-211
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 82kD
Human_gene_id: 3782
Human_swiss_prot_no: Q9UGI6
Subcellular_location: Membrane; Multi-pass membrane protein.
Other_name: Small conductance calcium-activated potassium channel protein 3 (SK3;SKCa 3;SKCa3;KCa2.3)
Background: potassium calcium-activated channel subfamily N member 3(KCNN3) Homo sapiens Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript v