KVβ1 rabbit pAb

Applications: IHC;IF
Reactivity: Human;Rat;Mouse
Source: Rabbit
Dilution: IHC 1:100-200
Immunogen: Synthetic Peptide of KVβ1 AA range: 66-116
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed_band(KD): 50kD
Human_gene_id: 7881
Human_swiss_prot_no: Q14722
Subcellular_location: Cytoplasm . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. .
Other_name: Voltage-gated potassium channel subunit beta-1 (K(+) channel subunit beta-1;Kv-beta-1)
Background: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes distinct isoforms which are encoded by alternatively spliced transcript variants of this gene. Some of these isoforms are beta subunits, which form heteromultimeric complexes with alpha subunits and modulate the activity of the pore-forming alp