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ELK Biotechnology
SKU:ES20671
MeCP2 rabbit pAb
MeCP2 rabbit pAb
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$250.00 USD
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Applications: WB
Reactivity: Human
Source: Rabbit
Dilution: WB: 1:2000
Immunogen: Synthetic Peptide of MeCP2 AA range: 313-363
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Observed_band(KD): 53kD
Human_gene_id: 4204
Human_swiss_prot_no: P51608
Subcellular_location: Nucleus . Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. .
Other_name: Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor
Reactivity: Human
Source: Rabbit
Dilution: WB: 1:2000
Immunogen: Synthetic Peptide of MeCP2 AA range: 313-363
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Observed_band(KD): 53kD
Human_gene_id: 4204
Human_swiss_prot_no: P51608
Subcellular_location: Nucleus . Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. .
Other_name: Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor
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