TLR8 rabbit pAb

Applications: IHC;IF
Reactivity: Human;Mouse;Rat
Source: Rabbit
Dilution: IHC: 1:200-500
Immunogen: Recombinant Protein of TLR8
Storage_stability: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Human_gene_id: 51311
Human_swiss_prot_no: Q9NR97
Subcellular_location: Endosome membrane ; Single-pass type I membrane protein . Endosomal localization confers distinctive proteolytic processing. .
Other_name: Toll-like receptor 8; CD288
Background: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008],